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Objective To understand the epidemiological characteristics of the cases of COVID-19 epidemic clusters, and explore the influence of family factors and social factors such as group activities on the spread of the disease. Methods The data of cases of COVID-19 epidemic clusters from 19 January, 2020 to 25 February, 2020 were collected from the official platforms of 36 cities in 6 provinces in China. Descriptive statistical methods, χ 2 test and curve fitting were used to analyze the epidemiological characteristics of the clustered cases. Results By 25 February, 2020, the data of 1 052 cases in 366 epidemic clusters were collected. In these clustered cases, 86.9%(914/1 050) occurred in families. Among the 1 046 cases with gender information, 513 were males (49.0%) and 533 were females (51.0%). The cases were mainly young adults between 18 and 59 years old, accounting for 68.5% (711/1 038). In the 366 epidemic clusters , the clusters in which the first confirmed cases with the history of sojourn in Wuhan or Hubei accounted for 47.0%(172/366). From 19 January to 3 February, 2020, the first confirmed cases with Wuhan or Hubei sojourn history accounted for 66.5%. From 4 to 25 February, the first confirmed cases who had Wuhan or Hubei sojourn history accounted for only 18.2%. The median of interval between the first generation case onset and the second generation case onset was 5 (2-8) days. The median of onset- diagnosis interval of the initial cases was 6 (3-9) days, and the median of onset-diagnosis interval of the secondary cases was 5 (3-8) days. Conclusions Epidemic clusters of COVID-19 were common in many cities outside Wuhan and Hubei. Close contact in family was one of the main causes for the spread of household transmission of the virus. After 4 February, the epidemic clusters were mainly caused by the first generation or second generation cases in local areas, and the time for diagnosis became shorter.
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Objective To evaluate the effect of three different doses of oxycodone hydrochloride injection on uterine cramping pain and emotion in patients of artificial abortion.Methods Four hundred female patients, aged 17-38 years, BMI 18.5-23.9 kg/m2, falling into ASA physical statusⅠ orⅡ, undergoing elective artificial abortion were randomized into four groups using a random number table:group O1 (oxycodone 0.06 mg/kg), group O2 (oxycodone 0.08 mg/kg), group O3 (oxycodone 0.1 mg/kg), and group F, 100 cases in each.In group O1, group O2 and group O3, oxycodone 0.06, 0.08, 0.1 mg/kg were intravenously injected respectively, while in group F fentanyl1μg/kg was intravenously injected.Then, propofol 2.5 mg/kg was intravenously injected as induced dose.The operation was started when eyelash reflexes disappeared, propofol 0.4 mg/kg was intravenously injected when body movement appeared during the operation.The propofol doses, operation time and recovery time were recorded.HR, MAP, RR before anesthesia (T0), when loss of eyelash reflex (T1), operation (T2) and recovery (T3) were recorded.The uterine cramping pain was assessed with numerical rating scale (NRS) at recovery, 10, 30, 60 min after operation.Patients'satisfaction was recorded after operation.Patients'emotion was assessed with positive and negative affect scale (PANAS) both before and after operation in one hour.Rescue analgesia, nausea and vomiting, dizziness, respiratory depression, pruritus, uroschesis, cognitive dysfunction, sweatiness were recorded.Results The propofol doses and recovery time in groups O2, O3 and F were significantly lower than those in group O1 (P<0.05).The NRS score of uterine cramping pain in groups O1, O2 and O3 were significantly lower than that in group F (P<0.05).Patients'satisfaction in groups O1, O2 and O3 were significantly higher than that in group F (P<0.05).The positive affective score after operation in one hour among the four groups were significantly higher than that before operation (P<0.05), and the negative affective score after operation in one hour among the four groups were significantly lower than that before operation (P<0.05).The positive affective score after operation in one hour in groups O1, O2 and O3 were significantly higher than that in group F (P<0.05), and the rescue analgesia in groups O1, O2 and O3 were significantly lower than that in group F (P<0.05).There were no significant differences among the four groups as to the dizziness, nausea and vomiting.No respiratory depression, pruritus, emergence agitation, cognitive dysfunction, uroschesis and sweatiness were reported.Conclusion Oxycodone 0.08 mg/kg combined with propofol in patients undergoing artificial abortion is effective in preventing uterine cramping pain.Furthermore, the patients'satisfaction and positive affective score can also be improved.
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Objective@#To explore the correlation of health literacy and mobile phone use dependence with psychopathological symptoms in middle school students.@*Methods@#22 628 middle school students in Shenyang, Bengbu, Xinxiang, Ulanqab, Chongqing and Yangjiang were enrolled by multistage cluster sampling method from November 2015 to January 2016. Chinese Adolescent Interactive Health Literacy Questionnaire (CAIHLQ), Self-rating Questionnaire for Adolescent Problematic Mobile Phone Use (SQAPMPU) and Multidimensional Sub-health Questionnaire of Adolescents (MSQA) were applied to acquire basic characteristics, health literacy, mobile phone use dependence and psychopathological symptoms of subjects. Subjects were classified into three groups, low level (<P25), medium level (P25-P75) and high level (>P75), according to the percentile of the questionnaire score. Multivariate logistic regression model was used to analyze the correlation of health literacy, mobile phone with psychopathological symptoms.@*Results@#The students were (15.4±1.8) years old with 10 990 boys (48.6%). The score of health literacy of students were (104.1±18.7) points. The rate of mobile phone use dependence was 25.4% (5 752/22 628) and the rate of psychopathological symptoms was 29.1% (6 581/22 628). Compared with high health literacy level, medium and low health literacy levels were related to psychopathological symptoms, with OR (95%CI) about 2.30 (2.10-2.52) and 5.40 (4.89-5.97), respectively. Compared with mobile phone use independence, mobile phone use dependence was related to psychopathological symptoms, with OR (95%CI) about 3.60(3.37-3.85). The highest rate of psychopathological symptoms occurred in students with mobile phone use dependence and low health literacy level [68.0% (1 345/1 977)], with OR (95%CI) about 19.59 (17.07-22.48).@*Conclusion@#Health literacy and mobile phone use dependence are related factors of psychopathological symptoms in middle school students.
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Objective@#To explore the clinical effects of antibiotic bone cement in the treatment of diabetic foot ulcers.@*Methods@#According to the treatment methods, 18 patients with diabetic foot ulcers (11 males and 7 females, aged 53-79 years), who were conformed to the study criteria and admitted to our hospital from January 2016 to January 2017, were enrolled in traditional group; 18 patients with diabetic foot ulcers (11 males and 7 females, aged 55-80 years), who were conformed to the study criteria and admitted to our hospital from February 2017 to February 2018, were enrolled in bone cement group. Wounds of patients in traditional group were treated with vacuum sealing drainage after conventional debridement. Wounds of patients in bone cement group were covered with antibiotic bone cement after conventional debridement. The number of patients with positive bacterial culture in wound exudate in the 2 groups on admission and 3, 6, 9, and 15 days after surgery, the length of hospital stay, the number of operation, and the wound complete healing time were retrospectively recorded. Data were processed with Fisher′s exact probability test and independent sample t test.@*Results@#Compared with (29±10) d and (4.6±1.2) times of patients in traditional group, the length of hospital stay [(9±3) d] of patients was obviously shortened, the number of operation [(1.3±0.6) times] of patients was obviously reduced, the number of patients with positive bacterial culture in wound exudate at each time point post surgery was obviously reduced (t=8.177, 9.896, P<0.05 or P<0.01) in bone cement group. There were no statistically significant differences in the number of patients with positive bacterial culture in wound exudate on admission and wound complete healing time between patients in the 2 groups (t=0.175, P>0.05).@*Conclusions@#The antibiotic bone cement treatment of diabetic foot ulcers can reduce the number of patients with positive bacterial culture in wound exudate and the number of operation, as well as shorten the length of hospital stay.
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Objective To investigate the interaction between health literacy,mobile phone dependence and unintentional injuries in middle school students,and to provide guidance for prevention on unintentional injuries in adolescents.Methods From November 2015 to January 2016,a questionnaire survey was conducted among 22 628 middle school students in Shenyang of Liaoning province,Bengbu of Anhui province,Xinxiang of Henan province,Ulanqab of Inner Mongolia Autonomous Region,Chongqing and Yangjiang of Guangdong province.Chinese Adolescent Interactive Health Literacy Questionnaire (CAIHLQ),Self-rating Questionnaire for Adolescent Problematic Mobile Phone Use (SQAPMPU),and Unintentional Injuries Assessment Scale and demographic variables were used to measure the health literacy,mobile phone dependence and unintentional injuries among the Chinese middle school students.Results The detection rates of mobile phone dependence and unintentional injuries were 25.4％ and 46.7％,respectively.The rates of unintentional injuries of middle school students with mobile phone dependence and with low,medium and high health literacy were 53.6％,44.4％ and 48.8％,48.1％,41.7％.Factors as mobile phone dependence,low and middle health literacy were positively related to unintentional injuries (OR=1.452,1.196,1.364).However,the multiplicative interaction between mobile phone dependence and health literacy on unintentional injuries was noticed significant (OR=1.217,95％CI:1.041-1.422).Conclusions Our results showed that the prevalence of unintentional injuries was relatively high in middle school students.Health literacy and mobile phone dependence seemed related to unintentional injuries.Interaction between health literacy and mobile phone dependence on unintentional injuries appeared significant.
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Objective To investigate the interaction between health literacy,mobile phone dependence and unintentional injuries in middle school students,and to provide guidance for prevention on unintentional injuries in adolescents.Methods From November 2015 to January 2016,a questionnaire survey was conducted among 22 628 middle school students in Shenyang of Liaoning province,Bengbu of Anhui province,Xinxiang of Henan province,Ulanqab of Inner Mongolia Autonomous Region,Chongqing and Yangjiang of Guangdong province.Chinese Adolescent Interactive Health Literacy Questionnaire (CAIHLQ),Self-rating Questionnaire for Adolescent Problematic Mobile Phone Use (SQAPMPU),and Unintentional Injuries Assessment Scale and demographic variables were used to measure the health literacy,mobile phone dependence and unintentional injuries among the Chinese middle school students.Results The detection rates of mobile phone dependence and unintentional injuries were 25.4％ and 46.7％,respectively.The rates of unintentional injuries of middle school students with mobile phone dependence and with low,medium and high health literacy were 53.6％,44.4％ and 48.8％,48.1％,41.7％.Factors as mobile phone dependence,low and middle health literacy were positively related to unintentional injuries (OR=1.452,1.196,1.364).However,the multiplicative interaction between mobile phone dependence and health literacy on unintentional injuries was noticed significant (OR=1.217,95％CI:1.041-1.422).Conclusions Our results showed that the prevalence of unintentional injuries was relatively high in middle school students.Health literacy and mobile phone dependence seemed related to unintentional injuries.Interaction between health literacy and mobile phone dependence on unintentional injuries appeared significant.
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Objective@#To examine the relationship between the prevalence of self-reported myopia and outdoor activities among middle school students and to explore the influence factors of the self-reported myopia.@*Methods@#A total of 12 979 participants were recruited from junior and senior middle school students in in Shenzhen, Nanchang, Zhengzhou and Shenyang by random cluster sampling method between December 2015 and March 2016. All participants completed an anonymous questionnaire to collect the information of demographic characteristics, self-reported myopia, outdoor activities, etc. 12 603 out of 12 979 copies of questionnaire were valid. The prevalence of self-reported myopia was compared among middle school students with different characteristics. Logistic regression models were used to analyze the relationship between myopia and outdoor activities.@*Results@#The prevalence of self-reported myopia among middle school students was 69.6% (8 766/12 603); which was separately 52.1% (1 216/2 335) in seventh grader, 61.6% (1 459/2 369) in eighth grader, 69.0%(1 470/2 129) in ninth grader, 80.0% (1 812/2 265) in freshmen, 79.4% (1 622/2 042) in sophomore, and 81.1%(1 187/1 463) in junior. The prevalence of self-reported myopia showed an increasing trend with the increase of grade (χ2=639.67, P<0.001). The prevalence of self-reported myopia was separately 63.5%(4 927/7 756) in non-myopic parents group, 78.0%(2 664/3 415)in either myopic parent group, and 82.1%(1 175/1 432) in both myopic parents group(χ2=328.28, P<0.001). Outdoor activities were associated with self-reported myopia. Binary logistic regression analysis showed that the risk of self-reported myopia was significantly increased by always staying at home in extracurricular time among the middle school students (OR=1.58, 95%CI: 1.36-1.82). The risk of self-reported myopia were significantly decreased by always physical exercise and recreational activities after school among middle school students: the ORs were separately 0.67 (95%CI: 0.57-0.78) for physical exercise and 0.77 (95%CI: 0.64-0.92) for recreational activities. After stratified analysis by the parents' myopia status, in non-myopic parents group, exercise and recreational activities after school among middle school students decreased the risk of myopia: the ORs were separately 0.68 (95%CI: 0.55-0.82) for physical exercise and 0.76 (95%CI: 0.61-0.95) for recreational activities; in either myopic parent group, OR(95%CI) were separately 0.65 (0.47-0.90) and 0.68 (0.47-0.98).@*Conclusion@#Outdoor activities was negatively associated with self-reported myopia among middle school students. However, the parents' myopia status may affect the protective effect.
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Objective@#To explore the relationship between adverse experience in childhood, social support, and physical and psychological sub-health status among middle school students in 3 cities in China.@*Methods@#15 278 adolescents were selected as subjects from 20 junior and senior middle schools located in 3 cities of China by stratified cluster sampling method. The survey collected the demographic information, ACEs, social support and physical-psychological status. A total of 14 820 valid questionnaires were retained for analysis. We assessed ACE score (count of six categories of childhood adversity), social support (adolescent social support questionnaire), and the prevalence of two outcomes: physiological and psychological sub-health status. Logistic regression was used to analyze the relationship between adverse childhood experiences, social support, and physiological and psychological sub-health status.@*Results@#The prevalence of physiological and psychological sub-health status were 26.4% (3 917/14 820) and 24.1%(3 572/14 820), respectively. A total of 89.4% (13 247/14 820) reported at least 1 adverse childhood experiences. The rates of physiological and psychological sub-health status were higher among girls (28.1%(2 092/7 443), 26.0%(1 932/7 443)) than boys (24.7%(1 825/7 377), 22.2%(1 640/7 377)). Among adolescents without ACEs, the rate of physiological and psychological sub-health status were 15.4%(243/1 573) and 10.4%(163/1 573), for those with 5-6 ACEs, the rate were 40.9%(636/1 556) and 43.6%(678/1 556). Among adolescents with higher social support, the rate of physiological and psychological sub-health status were 19.9%(724/3 635) and 13.0%(474/3 635) for those with lower social support, the rate of physiological and psychological sub-health status were 35.9%(1 403/3 913) and 39.0%(1 528/3 913). The rates of physiological and psychological sub-health status were higher with more ACE exposure or less social support. At each level of ACE exposure, physiological and psychological sub-health status were less in those with greater social support. For example, among adolescents reporting 5-6 ACEs, those in the lowest tertile of social support increased the risk of physiological sub-health status than those in the highest tertile (adjusted prevalence ratio (95%CI)=1.79 (1.23-2.56)); for those reporting no ACEs, the ratio was 3.04 (1.91-4.83). Among adolescents reporting 5-6 ACEs, those in the lowest tertile of social support increased the risk of psychological sub-health status than those in the highest tertile (adjusted prevalence ratio (95%CI)=3.77 (2.57-5.52)); for those reporting no ACEs, the ratio was 3.97(2.33-6.76).@*Conclusion@#The findings suggest that ACEs should be considered as risk factors for physiological and psychological sub-health status among middle school students. Across a range of exposures to ACEs, less social support was associated with more physiological and psychological sub-health status. Identifying those with ACE exposure who also have lower social support could be used to improve the health of adolescents.
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Objective@#The aim of this study was to describe the distribution of neck-shoulder symptoms among middle school students, and to explore its influence factors.@*Methods@#A cross-sectional survey was conducted on 24 middle schools in Shenyang, Zhengzhou and Shenzhen by purposive sampling method. In each middle school, 3 to 4 classes were selected from each grade all the students in the selected class would be recruited to the survey to investigate the demographic characteristics, neck-shoulder symptoms, physical exercise time, academic stress, screen behavior, sedentary behavior and other information by questionnaire. A total of 10 566 questionnaires were issued and 10 270 valid questionnaires were withdrawn. The prevalence of neck-shoulder symptoms among students were compared by different characteristics. Logistic regression models were applied to examine influencing factors associated with neck-shoulder symptoms.@*Results@#The prevalence of neck-shoulder symptoms among middle school students was 19.2% (1 968/10 270), while it was 22.6% (1 137/5 039) among girls and 15.9% (831/5 231) among boys; the difference showed statistical significance (P<0.001). The prevalence of neck-shoulder symptoms was separately 13.3% (253/1 901) in seventh grade, 16.8% (326/1 942) in eighth grade, 18.5% (299/1 617) in ninth grade, 21.8% (417/1 915) in sophomore, 21.4% (345/1 611) in junior, 25.5% (328/1 284) in senior; the difference showed statistical significance (P<0.001). The multivariate logistic regression analysis showed that in the last 3 months, students who always playing mobile phone ≥40 min continuously (OR=4.66, 95%CI: 3.95-5.49), watching TV ≥40 min continuously (OR=4.01, 95%CI: 3.39-4.73), using computer ≥40 min continuously (OR=3.61, 95%CI: 3.09-4.23), doing homework ≥60 min continuously (OR=3.25, 95%CI: 2.79-3.79), the average daily sitting time ≥10 h (OR=4.95, 95%CI: 4.25-5.77), and always sitting ≥90 min continuously (OR=5.18, 95%CI: 4.42-6.06) were risk factors of neck-shoulder symptoms.@*Conclusion@#The prevalence of neck-shoulder symptoms was high among middle school students in China, especially girls in senior grades. Long time, high frequency video behaviors and sedentary behaviors were related to the occurrence of neck-shoulder symptoms among middle school students.
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Objective To understand the gender specific association between early puberty and behavioral and emotional characteristics in children.Methods The questionnaire survey was conducted among the girls in grade 2-3,boys in grade 3-4 and both girls and boys in grade 7-8 selected through cluster sampling in 2 middle schools and 2 primary schools in Beijing and Shenyang respectively in November 2014.The questionnaire contents included general information,physical activity and video time,pubertal development scale (PDS) and strength and difficulties questionnaire (SDQ).Descriptive statistics were used to describe the prevalence of early puberty and the detection rate of abnormal behavioral problems.The effects of early puberty on behavioral and emotional problems were estimated with univariate and multivariate logistic regression analyses.The odds ratios and their 95％ confidence intervals were calculated.Results A total of 3 253 complete questionnaires were collected,the prevalence of early puberty was 15.9％ (518).The detection rate (number) of abnormal emotional symptoms,conduct problems,hyperactivity/inattention,peer relationship problems,pro-social behaviors and total difficulties were 8.3％ (269),9.1％ (297),6.5％ (211),16.4％ (534),9.2％ (299) and 13.8％(448) respectively.Multivariate logistic regression analysis showed that early puberty was the risk factor for conduct problems (OR=2.260,95％CI:1.322-3.863) and hyperactivity/inattention (OR=1.980,95％ CI:1.111-3.527) in the girls,and early puberty was risk factor for total difficulties in boys (95％CI:1.018-2.063).Conclusions Early puberty might increase the risk of conduct problems and hyperactivity/inattention in girls and increase the risk of total difficulties in boys.It is important to conduct gender specific psychological intervention among adolescents for improving their physical and mental health.
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Myopia has become a major health problem on global scale due to its increasing high prevalence in the past few decades and gradual younger onset age.Accumulated epidemiological surveys have shown that decreased time of exposure to sunlight would be an inducement for the development of myopia.Increasing time spent outdoors and exposure to sunlight might be the most cost-effective and effective measure for children to prevent myopia.This paper summarizes the progress in research of the association between sunlight exposure and myopia in children and its mechanisms to provide new clues for the research on myopia prevention and control.
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Objective To investigate the prevalence of suspected myopia among students and to examine the relationship between time spent on physical exercise,sleep,homework and suspected myopia.Methods A total of 8 030 primary and secondary school students from 4th to 12th grades were selected from the National Student Constitution and Health Survey (NSCHS) in Anhui province in 2014.Time spent on exercise,sleep and homework per day were collected using a self-administrated questionnaire.Visual acuity was examined using the Standard Logarithmic Visual Acuity Chart.Results The overall prevalence of suspected myopia was 69.03％.Prevalence rates of suspected myopia appeared higher in girls,in urban students,with the highest in the 16 to 18 year-old groups.Results from the multiple logistic regression analysis showed that the amount of time spent on physical exercise,sleep and homework per day were all significantly associated with suspected myopia.Suspected myopia was associated with longer time on physical exercise among students aged 8 to 12 years (OR=0.80,95％CI:0.64-0.99),and longer sleep time among students in the age groups of 13 to 15 years and 16 to 18 years (OR=0.73,95％CI:0.56-0.94;OR=0.38,95％CI:0.21-0.68,respectively).Longer time spent on homework significantly increased the risk of suspected myopia among students in the age groups of 8 to 12 years and 13 to 15 years (OR=1.41,95％CI:1.11-1.79;OR=1.74,95％ CI:1.36-2.23,respectively).Conclusion Suspected myopia appeared common among students.Comprehensive intervention programs focusing on sufficient physical exercise and sleep but less homework might help to prevent myopia among students at different ages.
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Myopia has become a major health problem on global scale due to its increasing high prevalence in the past few decades and gradual younger onset age.Accumulated epidemiological surveys have shown that decreased time of exposure to sunlight would be an inducement for the development of myopia.Increasing time spent outdoors and exposure to sunlight might be the most cost-effective and effective measure for children to prevent myopia.This paper summarizes the progress in research of the association between sunlight exposure and myopia in children and its mechanisms to provide new clues for the research on myopia prevention and control.
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Objective To investigate the prevalence of suspected myopia among students and to examine the relationship between time spent on physical exercise,sleep,homework and suspected myopia.Methods A total of 8 030 primary and secondary school students from 4th to 12th grades were selected from the National Student Constitution and Health Survey (NSCHS) in Anhui province in 2014.Time spent on exercise,sleep and homework per day were collected using a self-administrated questionnaire.Visual acuity was examined using the Standard Logarithmic Visual Acuity Chart.Results The overall prevalence of suspected myopia was 69.03％.Prevalence rates of suspected myopia appeared higher in girls,in urban students,with the highest in the 16 to 18 year-old groups.Results from the multiple logistic regression analysis showed that the amount of time spent on physical exercise,sleep and homework per day were all significantly associated with suspected myopia.Suspected myopia was associated with longer time on physical exercise among students aged 8 to 12 years (OR=0.80,95％CI:0.64-0.99),and longer sleep time among students in the age groups of 13 to 15 years and 16 to 18 years (OR=0.73,95％CI:0.56-0.94;OR=0.38,95％CI:0.21-0.68,respectively).Longer time spent on homework significantly increased the risk of suspected myopia among students in the age groups of 8 to 12 years and 13 to 15 years (OR=1.41,95％CI:1.11-1.79;OR=1.74,95％ CI:1.36-2.23,respectively).Conclusion Suspected myopia appeared common among students.Comprehensive intervention programs focusing on sufficient physical exercise and sleep but less homework might help to prevent myopia among students at different ages.
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Objective To investigate the characteristics on the time of sunshine exposure in Chinese primary and middle school students.Methods A total of 43 771 primary and middle school students were randomly selected from 12 provinces in China.A self-reported questionnaire was used to understand their time of sunshine exposure on weekdays and weekends as well as related family information and behaviors.x2 test was used to compare the hours of sunshine exposure among different groups.Multivariate logistic regression analysis was conducted to identify the influencing factors.Results Results from the current survey indicated that the average time of sunshine exposure on weekdays and weekends were 2.49 and 3.22 hours,respectively.On weekdays,proportions of students with time of sunshine exposure ≤2 h/d or ＞2 h/d were 60.81％ and 39.19％,respectively.On weekends,the proportions became 44.05％ and 55.95％,respectively.On weekdays,the time of sunshine exposure as ≤2 h/d was significantly different among factors as sex,urban or rural area,residential area,self-rating academic performance,type of housing or ways of commuting to school.On weekends,the time of sunshine exposure ≤2 h/d were significantly different among sex,residential areas,self-rating academic performance,type of housing and ways of commuting to school.Data from the multivariate logistic regression analysis showed that the limited sunshine exposure was significantly associated with factors as:type of primary schools,being girls,students living in the urban area or living in central or western areas,with normal or better academic performances,living in a fiat apartment and the time spent on watching video program ＞2 h/d both on weekdays and weekends.Conclusion The time of sunshine exposure seemed not enough among school students and significant differences were seen among different groups.
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Objective The main objective of this study is to explore the effect of liver function on the awake BIS value.Methods According to the Child-Pugh classification,65 patients were divid-ed into three groups.Group A (n=27):patients with normal liver function;group B (n=21):pa-tients with Child-Pugh A;group C (n=1 7):patients with Child-Pugh B-C.The awake BIS value at rest was measured.Results Total bilirubin (TBIL),direct bilirubin (DBIL),indirect bilirubin (IBIL),alanine aminotransferase (ALT),aspartate aminotransferase (AST),albumin (ALB)of group B and C were significantly poorer than group A (P <0.05 or P <0.01).The coagulation func-tion of group C was poorer than group A and B (P <0.01).Compared with group A (96.2 ± 1.7) and group B (95.6±0.8),the awake BIS value of group C (94.1±3.0)was significantly reduced (P<0.01).The awake BIS value was negatively correlated with the TBIL value (r = - 0.26,P =0.039).Conclusion The awake BIS value in end-stage liver disease patients was significantly lower than that in patients with normal liver function and mild liver dysfunction.The awake BIS value may be related with the amount of total bilirubin in the blood.
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Objective To explore the aesthetic efficacy of modified endoscopic rhytidectomy by using the techniques to minimize tissue damage,to obviate injury to the vessels and nerves,and to control bleeding and to firm fixation.Methods Two discontinuous incisions were made in the temporal scalp during the procedure,obviating injury to the branches of the superficial temporal vessels.Endoscopic technique was used to facilitate elevating,hemostasis,slinging and fixation in the plane under superficial temporal fascia.Three transverse incisions were made after the hairline in the forhead scalp,the operation was carried out by using endoscopic equipment,and the elevated forhead flap was slinged and fixed upward to the lamina externa cranii.Results 58 cases were received endoscopic forehead and temporal rhytidectomy,only slight edema was observed after surgery,and no obvisous ecchymosis was found.All patients returned home 7 days after operation.Degree of satisfaction on long-term follow-up showed that 56 cases(96.55%)improved obviously one year postoperatively;35 cases followed up 2 years,33(94.29%)of them improved obviously.None case was suffered from facial nerve injury.Conclusion The purpose of endoscopic rhytidectomy is to avoid carrying out the operation out of sight,to minimize unexpected damage to vessels and nerves,and to facilitate dissection,hemostasis,suturing,slingling and fixation.By refining the technique,we can achieve minimal injury,shorten recovery period,and obtain more satisfactory results,so the indication for operation is extended.
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Under the current circumstance that more and more students are being recruited in universities,ways have to be explored to promote the development of our major.The following three points including strength in construction of teaching staff,management of teaching quality and active participation in administration of students are suggested to be attempted,in combination with many other good ideas.
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Based on our long-time teaching practice,we tried to explore some measures of the teaching innovation about maternal and child health care,in terms of the innovation of course system,the compiling of teaching materials and the updating of teaching methods and skills.Through the discussion,we aimed to enhance our students' integrated qualities,cultivate and bring up more and more capable medical students of new-pattern fit for the social demands.
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<p><b>OBJECTIVE</b>This study was to determine the proliferating and biosynthetic characters of fibroblasts from abnormal scars and normal skins after complete contact in vitro.</p><p><b>METHODS</b>6 samples of keloid, hypertrophic scar and normal skin were collected respectively. Proliferation, inhibition and biosyntheses of different fibroblasts were investigated by detecting proliferating cell nuclear antigen(PCNA), P16, type I and III collagen proteins, and Pro alpha 1 (I) and Pro alpha 1 (III) procollagen gene expressions under the condition of fibroblast complete contact by means of cell culture, immunohistochemistry and molecular biological techniques, etc.</p><p><b>RESULTS</b>Overlap and high levels of proliferating activity and biosyntheses of complete contact fibroblasts from keloids indicated that these fibroblasts lost the behavior of contact inhibition and density inhibition. However, proliferating activity and biosynthetic function of complete contact fibroblasts from normal skins reduced dramatically. Biosynthetic function of complete contact fibroblasts from hypertrophic scars was still very strong, but proliferating activity was lower than keloid and higher than normal skin.</p><p><b>CONCLUSION</b>Proliferating and biosynthetic characters of complete contact fibroblasts from abnormal scars and normal skins were different, which may play an important role in the mechanisms of abnormal scar formation.</p>